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张国强

更新时间：2024-09-24 10:43:07点击次数：次

张国强，男，博士，副教授，硕士生导师，药物化学专业教师。2012年6月本科毕业于河北大学药学院；2015年6月于河北大学药学院获得药物化学硕士学位，期间在北京大学药学院进行联合培养，师从李建恒/叶新山教授；2018年6月于南开大学药学院获得化学生物学博士学位，师从王鹏/赵炜教授。2018年9月进入南开大学药物化学生物学国家重点实验室进行博士后研究；2023年7月回到河北大学药学院。目前主持一项国家级和一项省级课题，均在研；在Angew、Nat Comm、OCF、EJMC、ACS Materials Letters等学术期刊发表SCI论文十多篇，目前已经申请数十件专利，且有一项专利已经授权，且该专利正在转化。

邮箱：gqzhang@hbu.edu.cn

本人研究方向主要包括：1. 兼具抗凝与抗炎活性糖类新药的开发； 2. 基于糖苷酶的前药靶向递送。

主持或参加科研项目（课题）情况

  • 国家自然科学基金青年科学基金项目，抗体导向的酶催化诊疗一体化探针在肝癌模型中的应用，项目编号：52203171，2023.01 – 2025.12，30万，在研，主持

  • 河北省高等学校科学技术研究项目青年拔尖人才项目，在肝正常组织中淬灭的余辉探针在肝癌早期诊断和手术导航中的应用，10万，2024.01-2026.12，主持

  • 中央高校基本科研业务费青年教师启动项目，化学发光型纳米探针在肝癌诊断中的应用，2019. 01至2019. 12，3万元，结题，主持

    第一作者（含共同第一作者）与通讯作者论文

  1. Xingchen Duan,+ Guo-Qiang Zhang,+ Shenglu Ji, Yiming Zhang, Jun Li, Hanlin Ou, Zhiyuan Gao, Guangxue Feng, and Dan Ding* Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probe with Imaging-Modality Transformable Characteristics for Improved Biological Application. Angew. Chem. Int. Ed., 2022, 61, e202116174, https://doi.org/10.1002/anie.202116174 (IF=16.823, 中科院1区)

  2. Jisen Li#, Guo-Qiang Zhang#, Yufan Zhang, Youhong Tang, Dan Ding, Wen Li, Qian Liu. Building Highly Light-Harvesting Near-Infrared AIEgens Using Triazole-Based Luminescent Core for Improved Intravital Afterglow Imaging. Advanced Functional Materials, 2023, 2212380, https://doi.org/10.1002/adfm.202212380 (IF=19.9,中科院1区)

  3. Kang Li, Xingchen Duan, Zhiyong Jiang, Dan Ding, Yuncong Chen*, Guo-Qiang Zhang* & Zhipeng Liu*. J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging. Nat. Commun., 2021, 12, 2376. https://doi.org/10.1038/s41467-021-22686-z. (IF=17.694, 中科院1区)

  4. Guo-Qiang Zhang#, Hao Chang#, Zhiyuan Gao, Yang-ping Deng, Sheng Zeng, Luqing Shang, Dan Ding, Qian Liu. A neuraminidase-activatable NIR fluorescent probe for influenza virus ratiometric imaging in living cells and colorimetric detection on cotton swab. ACS Materials Letters, 2023, 5, 722−729. (IF= 11.1, 中科院1区)

  5. Hongzhen Jin, Qiang Chen, Yan-Yan Zhang, Kai-Feng Hao, Guo-Qiang Zhang* and Wei Zhao*. Preactivation-based, iterative one-pot synthesis of anticoagulant pentasaccharide fondaparinux sodium. Org. Chem. Front., 2019, 6, 3116-3120. (IF=5.456, 中科院1区)

  6. Guo-Qiang Zhang, Hongzhen Jin, Yunyan Zhao, Lina Guo, Xue Gao, Xiaoxue Wang, Shiyang Tie, Jie Shen, Peng George Wang, Hao Gan*, Huifei Cui*, Wei Zhao*. An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17. European Journal of Medicinal Chemistry, 2017, 126, 1039-1055. (IF=7.088, Q1)

  7. Guo-Qiang Zhang, Zhiyuan Gao, Jingtian Zhang, Hanlin Ou, Heqi Gao, Ryan T. K. Kwok, Dan Ding*, Ben Zhong Tang*. Wearable AIEgen-Based Lateral Flow Test Strip for Rapid Detection of SARS-CoV-2 RBD Protein and N Protein. Cell Reports Physical Science, 2022, https://doi.org/10.1016/j.xcrp.2022.100740 (IF=7.832, Q1)

  8. Guo-Qiang Zhang#, Weiwei Feng#, Zhiyuan Gao, Gao-Lan Zhang, Xinying Wu, Yating Xiao, Xun Li, Lei Zheng, Dan Ding, Jianshuang Guo*, Bo Situ*. A NIR ratiometric fluorescent biosensor for sensitive detection and imaging of α‑L‑fucosidase in living cells and HCC tumor-bearing mice. Aggregate, 2022, https://doi.org/10.1002/agt2.286. (即时IF>18.0)

  9. Huilin Xie, Jingtian Zhang, Chao Chen, Feiyi Sun, Haixiang Liu,Xinyuan He, Kristy W. K. Lam, Zhao Li, Jacky W. Y. Lam, Guo-Qiang Zhang,* Dan Ding, Ryan T. K. Kwok* and Ben Zhong Tang*. Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a “simple” AIE bioprobe. Mater. Chem. Front., 2021, 5, 1830-1835. (IF=8.683, Q1)

  10. Jing Gao‡, Junhua Wang‡, Xin Yue, Yuanzhu Zhou, Minghui Wang, Yiqing Sun, Qianyu Zhang, Zhiyuan Gao, Guo-Qiang Zhang*, Jing Shen*and Dan Ding*. Photostable Aggregation-Induced Emission Photosensitizer Nanoparticle/Hyaluronic Acid Hydrogel for Efficient Photodynamic Tooth Bleaching. ACS Applied Nano Materials, 2022, https://doi.org/10.1021/acsanm.1c03912. (IF=6.14, Q2)

  11. Yifang Huang‡, Weiwei Feng‡, Guo-Qiang Zhang‡, Yuling Qiu, Linlin Li, Liqiu Pan, Nannan Cao*. An Enzyme-activatable Dual-readout Probe for Sensitive β-Galactosidase Sensing and Escherichia Coli analysis. Frontiers in Bioengineering and Biotechnology, 2022, DOI: 10.3389/fbioe.2022.1052801 (IF=6.064, Q1).

  12. Hongzhen Jin, Kaixuan Wang, Kerui Ma, Wei Zhao, Guo-Qiang Zhang*. Preparation of rare L-idose derivatives from D-glucofuranose via neighboring acyl group assistance. Tetrahedron Letters, 2021, 73, 153135. (IF=2.032, Q3)

其它论文

  1. Guangxue Feng, Guo-Qiang Zhang, Dan Ding. Design of superior phototheranostic agents guided by Jablonski diagrams. Chem. Soc. Rev., 2020, 49, 8179-8234.

  2. Yao B, Zhao J, Ding S, Giel M-C, Zhang G, Ding D, Tang Y, Weng ZH, Hong Y, A novel red-emitting aggregation-induced emission probe for determination of β-glucosidase activity, Biomaterials (2023), doi: https://doi.org/10.1016/j.biomaterials.2023.122046.

  3. Zhang Yanyan, Hao Kaifeng, Zhang Guoqiang*, Zhao Wei. β-Stereoselectivity of Glucuronic Acid Analogues Mediated by 2-Cyanobenzyl Group. Chemical Journal of Chinese Universities, 2019, 40, 1904-1910.

  4. Jianshuang Guo, Guoqiang Zhang, Jing Ma, Caili Zhao, Qingqing Xue, Jiyan Wang, Wenjie Liu, Kaihui Liu, Haifeng Wang, Ning Liu, Qitao Song and Jing Li*. Detection and identification of O-GlcNAc-modified proteins using 6-azido-6-deoxy-N-acetyl-galactosamine. Org. Biomol. Chem., 2019, 17, 4326.

专利  

1.  赵炜，张国强，金洪真，王凯旋. 肝素五糖结构化合物, 公开(公告)号：CN114957354A（已授权）

2. 丁丹，张国强，唐本忠，郑磊，司徒博. 一种2019-nCoV新型冠状病毒抗体检测装置, 申请号：2020120186324.X

3. 丁丹，张国强，唐本忠，郑磊，司徒博. 一种2019-nCoV新型冠状病毒抗原检测装置, 申请号：202020185671.0

4. 丁丹，张国强，唐本忠，郑磊，司徒博. 一种2019-nCoV新型冠状病毒抗体检测试剂及检测装置, 申请号：202010103382.6

5. 丁丹，张国强，唐本忠，郑磊，司徒博. 一种2019-nCoV新型冠状病毒抗原检测试剂及检测装置, 申请号：202010103222.1

6. 丁丹，郑磊，司徒博，张国强.一种新型抗体检测试剂及其制备方法, 申请号：202010103200.5

7. 丁丹，郑磊，司徒博，张国强. 一种新型抗原检测试剂及其制备方法, 申请号：202010103204.3

8. 丁丹，高贺麒，张国强，章经天. 一种AIE分子及其合成方法, 申请号：202010105787.3

9. 丁丹，郑磊，司徒博，张国强. 一种新型特异性蛋白检测试剂及其制备方法, 申请号：202010103205.8

 

(编辑：姜浩)

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